Does Dalbergia Sissoo Leaves Possess Anti-ulcer Activity: an Experimental Study in Alcohol and Aspirin Induced Ulcerative Rat Models

Ulcer is a common problem associated with NSAID’s use. The use of plants to treat and cure diseases is common practice since ancient times because of people blind faith on safety of plant’s use. The present study aimed to evaluate anti-ulcer activity of Dalbergia sissoo in alcohol and aspirin induced ulcerative rat models. Animals were divided into four groups. Group I was disease control, group II received standard drug and III-IV groups were administered leaves ethanol extract (orally) at 100 mg/kg and 200 mg/kg dose levels. Cumulative ulcer index score was calculated and anti-ulcer activity was determined on the basis of this calculated score. Results revealed significant anti-ulcer activity of leaves ethanol extract at 200 mg/kg dose in both ulcer models. This study provides scientific evidence of folklore use of leaves of Dalbergia sissoo in ulcer.